I think Star Trek TOS might be the most fun thing to mashup.
This was a scene with Spock and Lieutenant Commander Ann Mulhall who was an Astrobiology expert.
… and some really sweaty guy.
I haven’t seen this episode in ages, it was called Return to Tomorrow. All I remember is that there was body swapping involved. Anyways, that was the screenshot that I used.
It is Holmes vs. Holmes in a Street Fighter deathmatch.
ie: Baker Street Fighter